Cat. No. 5399

BTB1 C12H8ClNO4S [86030-08-2]

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Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene

Biological Activity

Selective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.

Technical Data

Soluble to 100 mM in DMSO and to 20 mM in ethanol
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554. PMID: 25402598.

Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072. PMID: 19856362.

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Citations are publications that use Tocris products.

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Keywords: BTB1, supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Tocris Bioscience, Kinesin Inhibitor products

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