Cat. No. 5399
Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)
Biological ActivitySelective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554. PMID: 25402598.
Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072. PMID: 19856362.
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Keywords: BTB1, supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Tocris Bioscience, Kinesin Inhibitor products