Cat. No. 5399
Chemical Name: 4-Chloro-2-nitro-1-(phenylsulfonyl)
Biological ActivitySelective and ATP-competitive mitotic kinesin Kif18A inhibitor (IC50 = 1.7 μM); reversibly inhibits microtubule-stimulated Kif18A ATPase activity. Displays selectivity against a panel of other mitotic kinesins.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Braun et al (2014) Synthesis and biological evaluation of optimized Inhibitors of the mitotic kinesin Kif18A. ACS Chem.Biol. 10 554. PMID: 25402598.
Catarinella et al (2009) BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew.Chem.Int.Ed.Engl. 48 9072. PMID: 19856362.
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Keywords: BTB1, supplier, Selective, reversible, ATP-competitive, mitotic, Kinesins, Kif18A, inhibitors, inhibits, microtubule, mitosis, Tocris Bioscience, Kinesin Inhibitor products