A01

Cat. No. 5397

A01 C22H20ClF3N4O3S [1007647-73-5]

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Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)phenyl]sulfonyl]-1-piperazinyl][4-(5-methyl-1H-pyrazol-1-yl)phenyl]methanone

Biological Activity

High affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.

Technical Data

M.Wt:
512.93
Formula:
C22H20ClF3N4O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1007647-73-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cao et al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965. PMID: 24828823.

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Keywords: A01, supplier, A01, bone, morphogenetic, proteins, high, affinity, smurf1, e3, ubiquitin, ligase, inhibitors, inhibits, smad, osteoblasts, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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