Cat. No. 5397
Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)ph
Biological ActivityHigh affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Cao et al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965. PMID: 24828823.
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Keywords: A01, supplier, A01, bone, morphogenetic, proteins, high, affinity, smurf1, e3, ubiquitin, ligase, inhibitors, inhibits, smad, osteoblasts, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products