Cat. No. 5397
Chemical Name: [4-[[4-Chloro-3-(trifluoromethyl)ph
Biological ActivityHigh affinity Smurf1 E3 ubiquitin ligase inhibitor (Kd = 3.7 nM). Attenuates Smurf1-mediated Smad 1/5 degradation and enhances BMP signaling. Potentiates BMP-2-induced osteoblastic activity in C2C12 myoblasts and MC3T3-E1 osteoblast precursor cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cao et al (2014) Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci.Rep. 4 4965. PMID: 24828823.
If you know of a relevant reference for A01 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses A01 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: A01, supplier, A01, bone, morphogenetic, proteins, high, affinity, smurf1, e3, ubiquitin, ligase, inhibitors, inhibits, smad, osteoblasts, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenicLenalidomide
Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligasecis VH 298
Negative control for VH 298VH 298
High-affinity inhibitor of VHLcis MZ 1
Negative Control for MZ1MZ 1
(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.