Cat. No. 5391
Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethyny
Biological ActivityPotent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Dinér et al (2012) Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 55 4872. PMID: 22559926.
Klein et al (2011) Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 6 e20789. PMID: 21698101.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses SPP 86 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SPP 86, supplier, SPP86, RET, REarranged, during, Transfection, tyrosine, kinases, potent, inhibitors, inhibits, antiproliferative, Tocris Bioscience, Other RTKs Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective PDGFR inhibitorGSK 1363089
Potent inhibitor of MET, VEGFR2, Ron and AXLPF 06273340
Potent and selective pan-Trk inhibitor; peripherally restricted
April 1 - 5, 2017
Washington, D.C., USA