Cat. No. 5391
Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethyny
Biological ActivityPotent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Dinér et al (2012) Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 55 4872. PMID: 22559926.
Klein et al (2011) Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 6 e20789. PMID: 21698101.
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Keywords: SPP 86, supplier, SPP86, RET, REarranged, during, Transfection, tyrosine, kinases, potent, inhibitors, inhibits, antiproliferative, Tocris Bioscience, Other RTKs Inhibitor products
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