SPP 86

Cat. No. 5391

SPP 86 C16H15N5 [1357349-91-7]

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Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Biological Activity

Potent RET inhibitor (IC50 = 8 nM). Also exhibits inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. Inhibits proliferation of HCT 116 and TPC1 cells in vitro. Cell permeable.

Technical Data

M.Wt:
277.32
Formula:
C16H15N5
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1357349-91-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Dinér et al (2012) Preparation of 3-substituted-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amines as RET kinase inhibitors. J.Med.Chem. 55 4872. PMID: 22559926.

Klein et al (2011) Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases. PLoS ONE 6 e20789. PMID: 21698101.

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Keywords: SPP 86, supplier, SPP86, RET, REarranged, during, Transfection, tyrosine, kinases, potent, inhibitors, inhibits, antiproliferative, Tocris Bioscience, Other RTKs Inhibitor products

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