Ro 48-8071 fumarate

Cat. No. 5389

Ro 48-8071 fumarate C23H27BrFNO2.C4H4O4 [189197-69-1]

Price and Availability

For Ro 48-8071 fumarate pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

Biological Activity

2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Technical Data

Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265. PMID: 23441171.

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795. PMID: 21315634.

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J.Lipid.Res. 38 373. PMID: 9162756.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Ro 48-8071 fumarate from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Ro 48-8071 fumarate, supplier, Ro48-8071, fumarate, 2,3-Oxidosqualene, OSC, inhibitors, inhibits, cholesterol, synthesis, Ebola, virus, EBOV, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

New Product Guide (Spring/Summer 2016)

Our New Product guide highlights over 110 new products added in the first half of 2016. View PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.