Ro 48-8071 fumarate

Cat. No. 5389

Ro 48-8071 fumarate C23H27BrFNO2.C4H4O4 [189197-69-1]

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Chemical Name: (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone

Biological Activity

2,3-Oxidosqualene cyclase (OSC) inhibitor (IC50 = 6.5 nM); blocks cholesterol synthesis in HepG2 cells. Reduces viability of breast cancer cell lines. Also inhibits Ebola virus (EBOV) cell entry (IC50 = 1.74 μM).

Technical Data

M.Wt:
564.44
Formula:
C23H27BrFNO2.C4H4O4
Solubility:
Soluble to 20 mM in water with gentle warming and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
189197-69-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Shoemaker et al (2013) Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection. PLoS One. 8 e56265. PMID: 23441171.

Grinter et al (2011) An inverse docking approach for identifying new potential anti-cancer targets. J.Mol.Graph Model. 29 795. PMID: 21315634.

Morand et al (1997) Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J.Lipid.Res. 38 373. PMID: 9162756.

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Keywords: Ro 48-8071 fumarate, supplier, Ro48-8071, fumarate, 2,3-Oxidosqualene, OSC, inhibitors, inhibits, cholesterol, synthesis, Ebola, virus, EBOV, Tocris Bioscience, Other Lipid Metabolism Inhibitor products

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