ML 354

Cat. No. 5387

ML 354 C16H14N2O3 [89159-60-4]

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Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol

Biological Activity

Selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.

Technical Data

M.Wt:
282.29
Formula:
C16H14N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
89159-60-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708. PMID: 25176330.

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Keywords: ML 354, supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Tocris Bioscience, Protease-Activated Receptor Antagonist products

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