Cat. No. 5387
Chemical Name: 1-Methyl-5-nitro-3-phenyl-1H-indole
Biological ActivitySelective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708. PMID: 25176330.
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Citations are publications that use Tocris products.
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Keywords: ML 354, supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Tocris Bioscience, Protease-Activated Receptor Antagonist products
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