Cat. No. 5385
Chemical Name: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6
Biological ActivityPotent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Demont et al (2014) 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 5 1190. PMID: 25408830.
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Keywords: GSK 5959, supplier, GSK5959, potent, selective, BRPF1, bromodomains, inhibitors, inhibits, cell, permeable, Tocris Bioscience, Bromodomain Inhibitor products
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