Cat. No. 5385
Chemical Name: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6
Biological ActivityPotent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Demont et al (2014) 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 5 1190. PMID: 25408830.
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Keywords: GSK 5959, supplier, GSK5959, potent, selective, BRPF1, bromodomains, inhibitors, inhibits, cell, permeable, Tocris Bioscience, Bromodomain Inhibitor products
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