Cat. No. 5385
Chemical Name: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6
Biological ActivityPotent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Demont et al (2014) 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 5 1190. PMID: 25408830.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GSK 5959 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: GSK 5959, supplier, GSK5959, potent, selective, BRPF1, bromodomains, inhibitors, inhibits, cell, permeable, Tocris Bioscience, Bromodomain Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent BRD9/7 inhibitorBAY 299
Potent and selective BRD1 and TAF1 inhibitorNVS-CECR2-1
Potent and selective inhibitor of cat eye syndrome chromosome region, candidate 2 (CECR2)NI 42
High affinity BRPF inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.