Cat. No. 5385
Chemical Name: N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6
Biological ActivityPotent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Demont et al (2014) 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 5 1190. PMID: 25408830.
If you know of a relevant reference for GSK 5959 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses GSK 5959 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: GSK 5959, supplier, GSK5959, potent, selective, BRPF1, bromodomains, inhibitors, inhibits, cell, permeable, Tocris Bioscience, Bromodomain Inhibitor products
Find multiple products by catalog number
New Products in this Area
Histone H3 peptideTC AC 28
High affinity BET bromodomain ligandTP 472N
Negative control for TP 472 (Cat. No. 6000).TP 472
Potent BRD9/7 inhibitorBAY 299
Potent and selective BRD1 and TAF1 inhibitor
August 20 - 24, 2017
Paris , France