Cat. No. 5384
Chemical Name: 4-(2-(2-Fluorophenyl)-4-(fluorophen
Biological ActivityInduces cardiomyocyte differentiation from human embryonic stem cells following mesoderm induction. Potently inhibits p38α, CK1δ and CK1ε (IC50 values are 20, 32 and 32 nM respectively).
Licensing InformationSold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Bioprocessing Technology Institute.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Laco et al (2014) Cardiomyocyte differentiation of pluripotent stem cells with SB203580 analogues correlates with Wnt pathway CK1 inhibition independent of p38 MAPK signaling. J.Mol.Cell.Cardiol. PMID: 25528965.
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Keywords: TA 02, supplier, TA02, induces, cardiomyocyte, differentiation, human, pluripotent, stem, cells, hpsc, inhibits, inhibitors, ck1eta, ck1e, ck1δ, ck1delta, ck1d, ck1ε, p38alpha, p38a, p38α, mapk, casein, kinase, Tocris Bioscience, ESCs and iPSCs products