C16

Cat. No. 5382

C16 C13H8N4OS [608512-97-6]

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Chemical Name: 6,8-Dihydro-8-(1H-imidazol-5-ylmethylene)-7H-pyrrolo[2,3-g]benzothiazol-7-one

Biological Activity

PKR inhibitor (IC50 = 210 nM). Rescues PKR-dependent translation block in vitro. Decreases Aβ42-induced inflammatory cytokine release and apoptosis in neuronal cultures. Prevents neuroinflammation and neuronal loss in an acute excitotoxic rat model. Brain penetrant.

Technical Data

M.Wt:
268.29
Formula:
C13H8N4OS
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
608512-97-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Tronel et al (2014) The specific PKR inhibitor C16 prevents apoptosis and IL-1 production in an acute excitotoxic rat model with a neuroinflammatory component. Neurochem.Int. 64 73. PMID: 24211709.

Couturier et al (2011) Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J.Neuroinflammation 8. PMID: 21699726.

Ingrand et al (2007) The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett. 581 4473. PMID: 17761171.

Jammi et al (2003) Small molecule inhibitors of the RNA-dependent protein kinase. Biochem.Biophys.Res.Comm. 308 50. PMID: 12890478.

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Keywords: C16, supplier, Double-stranded, RNA-dependent, proteins, kinases, PKR, inhibitors, inhibits, neuroprotective, neuroprotection, neuroinflammation, Tocris Bioscience, Other Kinase Inhibitor products

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