ML 297

Cat. No. 5380

ML 297 C17H14F2N4O [1443246-62-5]

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Chemical Name: N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

Biological Activity

Selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). Exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents PTZ-induced epileptic seizures in mice. Brain penetrant.

Technical Data

M.Wt:
328.32
Formula:
C17H14F2N4O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1443246-62-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kaufmann et al (2013) ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4 1278. PMID: 23730969.

Wen et al (2013) Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg.Med.Chem.Lett. 23 4562. PMID: 23838260.

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Citations are publications that use Tocris products.

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Keywords: ML 297, supplier, ML297, selective, Kir3.1, GIRK1, channels, activators, inward, rectifying, rectifiers, potassium, K+, epilepsy, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products

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