VU 0469650 hydrochloride
Cat. No. 5379
Chemical Name: 3-[(3R)-3-Methyl-4-(tricyclo[3.3.1.
Biological ActivityPotent and selective negative allosteric modulator of mGlu1 (IC50 = 99 nM). Exhibits >100-fold selectivity for mGlu1 over mGlu2-8 and 68 other GPCRs, ion channels, kinases and transporters. Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lovell et al (2013) N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: Identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg.Med.Chem.Lett. 23 3713. PMID: 23727046 .
If you know of a relevant reference for VU 0469650 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses VU 0469650 hydrochloride from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: VU 0469650 hydrochloride, supplier, VU0469650, hydrochloride, modulators, metabotropic, glutamate, receptor, mGlu1, mGluR1, allosteric, negative, potent, selective, NAMs, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Modulator products