Cat. No. 5378
Alternative Name: ML 396
Chemical Name: N-[3-Chloro-4-[(5-chloro-2-pyridiny
Biological ActivityGroup III mGlu receptor positive allosteric modulator (EC50 values are 108, 125 and 146 nM for mGlu4, mGlu8 and mGlu7 respectively). Exhibits selectivity over a panel of 68 other GPCRs, ion channels and transporters. Potentiates mGlu7-mediated reductions in excitatory post synaptic potentials in hippocampal slices.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Jalan-Sakrikar et al (2014) Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem.Neurosci. 5 1221. PMID: 25225882.
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Keywords: VU 0422288, supplier, VU0422288, ML396, groupIII, mglu4, mglu8, mglu7, metabotropic, receptors, positive, allosteric, modulators, selective, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Modulator products