Pregnenolone sulfate sodium salt
Cat. No. 5376
Chemical Name: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt
Biological ActivityHighly potent neurosteroid; enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 = ~2 pM) and potentiates NMDA responses. Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Smith et al (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 86 390. PMID: 25057049.
Majeed et al (2010) Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 161 430. PMID: 20735426.
Li et al (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 323 236. PMID: 17636008.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Pregnenolone sulfate sodium salt include:
Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845. PMID: 21371490.
Do you know of a great paper that uses Pregnenolone sulfate sodium salt from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Pregnenolone sulfate sodium salt, supplier, neuroactive, steroids, highly, potent, NMDA, TRPM3, memory, LTP, potentiators, activates, activators, GABA, Tocris Bioscience, NMDA Receptor products
Find multiple products by catalog number
New Products in this Area
NMDA receptor modulator; metabolite of Ketamine hydrochloride (Cat. No.3131)2S,6S-Hydroxynorketamine hydrochloride
Potent AMPA agonist; antidepressant2R,6R-Hydroxynorketamine hydrochloride
Potent AMPA agonist; lacks ketamine-related side effects(R)-Norketamine hydrochloride
NMDA receptor modulator; metabolite of Ketamine hydrochloride (Cat. No.3131).PEAQX tetrasodium salt
Potent NMDA receptor antagonist; NR2A selective
One Day Symposium
March 1, 2017
Amsterdam, The Netherlands