Pregnenolone sulfate sodium salt

Cat. No. 5376

Pregnenolone sulfate sodium salt C21H31NaO5S [1852-38-6]

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Chemical Name: (3β)-3-(Sulfooxy)-pregn-5-en-20-one sodium salt

Biological Activity

Highly potent neurosteroid; enhances intracellular Ca2+ upon NMDA receptor-mediated synaptic activity (EC50 = ~2 pM) and potentiates NMDA responses. Activates CREB phosphorylation, augments LTP and cognitive behavior in rat memory models. Also activates TRPM3 channels.

Technical Data

M.Wt:
418.52
Formula:
C21H31NaO5S
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Storage:
Store at +4°C
CAS No:
1852-38-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Smith et al (2014) A role for picomolar concentrations of pregnenolone sulfate in synaptic activity-dependent Ca2+ signaling and CREB activation. Mol.Pharmacol. 86 390. PMID: 25057049.

Majeed et al (2010) Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels. Br.J.Pharmacol. 161 430. PMID: 20735426.

Li et al (2007) Neuroactive steroids and human recombinant rho1 GABAC receptors. J.Pharmacol.Exp.Ther. 323 236. PMID: 17636008.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Pregnenolone sulfate sodium salt include:

Luoma et al (2011) Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity. Steroids 76 845. PMID: 21371490.

Do you know of a great paper that uses Pregnenolone sulfate sodium salt from Tocris? If so please let us know.

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Keywords: Pregnenolone sulfate sodium salt, supplier, neuroactive, steroids, highly, potent, NMDA, TRPM3, memory, LTP, potentiators, activates, activators, GABA, Tocris Bioscience, NMDA Receptor products

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