Cat. No. 5373
Alternative Name: TLR4-IN-C34
Chemical Name: 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyr
Biological ActivityTLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Neal et al (2013) Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One 8 e65779. PMID: 23776545.
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Keywords: C34, supplier, TLR4, signaling, mediated, inflammatory, diseases, inhibitors, inhibits, endotoxemia, necrotizing, enterocolitis, NEC, Tocris Bioscience, Toll-like Receptor Inhibitor products
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