C34

Cat. No. 5373

C34 C17H27NO9 [40592-88-9]

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Alternative Name: TLR4-IN-C34

Chemical Name: 1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate

Biological Activity

TLR4 inhibitor; attenuates TLR4 signaling in enterocytes and macrophages in vitro, and reduces systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis (NEC). Also suppresses LPS signaling in human ileum displaying NEC ex-vivo. Displays no significant effects on signaling via TLR2 or TLR9.

Technical Data

M.Wt:
389.4
Formula:
C17H27NO9
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
40592-88-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Neal et al (2013) Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One 8 e65779. PMID: 23776545.

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Keywords: C34, supplier, TLR4, signaling, mediated, inflammatory, diseases, inhibitors, inhibits, endotoxemia, necrotizing, enterocolitis, NEC, Tocris Bioscience, Toll-like Receptor Inhibitor products

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