Cat. No. 5371
Chemical Name: 1-[(4-Chlorophenyl)methyl]-2-(1-pyr
Biological ActivityTRPC5 channel blocker (IC50 values are 1.1, 6.4, 9.1, 11.3 and 26.5 μM for TRPC5, TRPC4, TRPC3, TRPC6 and TRPC7 respectively). Exhibits minimal effect on TRPM3, TRPM8 and TRPV1-4 channels. Also histamine H1 receptor antagonist and anticonvulsant in zebrafish Dravet syndrome model.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Richter et al (2014) Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol.Pharm. 86 514. PMID: 25140002.
Baraban et al (2013) Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. Nat.Commun. 4 2410. PMID: 24002024.
Aguilar et al (1986) Pharmacological investigation into the effects of histamine and histamine analogues on guinea-pig and rat colon in vitro. Br.J.Pharmacol. 88 501. PMID: 3742147.
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Keywords: Clemizole hydrochloride, supplier, transient, potential, channels, TRPC5, histamine, receptors, blockers, antagonists, Tocris Bioscience, TRPC Blocker products
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July 8 - 12, 2017