Norleual

Cat. No. 5369

Norleual Nle-Tyr-Leu-(Ψ(CH2-NH)-His-Pro-Phe

Price and Availability

For Norleual pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Angiotensin IV analog. Highly potent HGF/c-MET inhibitor (IC50 = 3 pM). Inhibits HGF-induced MDCK cell proliferation and invasion in vitro. Also AT4 receptor antagonist; disrupts LTP stabilization. Antiangiogenic.

Technical Data

M.Wt:
774.95
Formula:
C41H58N8O7
Sequence:
XYLHPF

(Modifications: X = Nle, Leu-3-His-4 peptide bond replaced with CH2NH)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
334994-34-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Yamamoto et al (2010) The angiotensin IV analog Nle-Tyr-Leu-psi-(CH2-NH2)3-4-His-Pro-Phe (norleual) can act as a hepatocyte growth factor/c-Met inhibitor. J.Pharmacol.Exp.Ther. 333 161. PMID: 20086056.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses Norleual from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: Norleual, supplier, potent, HGF, c-MET, hepatocyte, growth, factors, HGF/c-MET, inhibits, inhibitors, antiangiogenic, angiogenesis, tyrosine, kinases, angiotensin, IV, analog, receptors, AT4, antagonists, Tocris Bioscience, MET Receptor Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

New Products in this Area

CP 673451

Potent and selective PDGFR inhibitor

GSK 1363089

Potent inhibitor of MET, VEGFR2, Ron and AXL

PF 06273340

Potent and selective pan-Trk inhibitor; peripherally restricted

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.