Cat. No. 5367
Chemical Name: 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(py
Biological ActivityPotent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets.
Licensing InformationThis probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.
External Portal InformationChemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Kaniskan et al (2015) A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl 54 5166. PMID: 25728001.
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Keywords: SGC 707, supplier, SGC707, Potent, allosteric, inhibitors, inhibits, of, protein, arginine, methyltransferase, 3, PRMT3, Tocris Bioscience, Protein Arginine Methyltransferase Inhibitor products
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