LLY 507

Cat. No. 5365

LLY 507 C36H42N6O [1793053-37-8]

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Chemical Name: 3-Cyano-5-[2-[4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl]phenyl]-N-[3-(pyrrolidin-1-yl)propyl]benzamide

Biological Activity

Potent SMYD2 inhibitor (IC50 = 15 nM). Exhibits >100-fold selectivity for SMYD2 over 25 other methyltransferases including SMYD3, SUV420H1 and SUV420H2. Inhibits SMYD2-mediated p53 methylation in vitro. Also inhibits proliferation of a range of esophageal, liver and breast cancer cell lines.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the LLY 507 probe summary on the SGC website.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of LLY 507 is reviewed on the chemical probes website.

Technical Data

M.Wt:
574.76
Formula:
C36H42N6O
Solubility:
Soluble to 100 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
1793053-37-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Nguyen et al (2015) LLY-507, a cell-active, potent, and selective inhibitor of protein-lysine methyltransferase SMYD2. J.Biol.Chem. 290 13641. PMID: 25825497.

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Keywords: LLY 507, supplier, LLY507, potent, selective, SMYD2, inhibitors, inhibits, lysine, methyltransferases, p53, Tocris Bioscience, Lysine Methyltransferase Inhibitor products

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