Cat. No. 5363
Chemical Name: Methyl 1-hydroxy-6-phenyl-4-(trifluorometh
Biological ActivityLDHA inhibitor; reduces lactate production in HeLa cells. Inhibits cell growth of LPC006 and PANC-1 cells in vitro. Also enhances the antiproliferative effects of Gemcitabine (Cat. No. 3259) on LPC006 and PANC-1 cells.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Maftouh et al (2014) Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia. Br.J.Cancer 110 172. PMID: 24178759.
Calvaresi et al (2013) Dual targeting of the Warburg effect with a glucose-conjugated lactate dehydrogenase inhibitor. Chembiochem 14 2263. PMID: 24174263.
Granchi et al (2013) Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org.Biomol.Chem. 11 6588. PMID: 23986182.
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Keywords: NHI 2, supplier, NHI2, C17H12F3NO3, LDHA, inhibitors, lactate, dehydrogenases, antiproliferative, inhibits, Tocris Bioscience, Lactate Dehydrogenase A Inhibitor products