TASP 0433864

Cat. No. 5362new

TASP 0433864 C18H23N3O3 [1431980-60-7]

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Chemical Name: (2S)-2-[[4-(1,1-Dimethylethyl)phenoxy]methyl]-2,3-dihydro-5-methylimidazo[2,1-b]oxazole-6-carboxamide

Biological Activity

Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV (Cat. No. 0975) on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.

Technical Data

M.Wt:
329.39
Formula:
C18H23N3O3
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1431980-60-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hiyoshi et al (2014) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 351 642. PMID: 25277141.

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Keywords: TASP 0433864, supplier, TASP0433864, metabotropic, glutamate, receptors, 2, positive, allosteric, modulators, modulates, mGlu2, mGluR, selective, PAM, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Modulator products

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