Rifaximin

Cat. No. 5359

Rifaximin C43H51N3O11 [80621-81-4]

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Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione

Biological Activity

Pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.

Technical Data

M.Wt:
785.88
Formula:
C43H51N3O11
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
80621-81-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559. PMID: 25277138.

Stradi et al (2010) Structural elucidation of the Rifaximin Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858. PMID: 19926422.

Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67. PMID: 15855749.

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Keywords: Rifaximin, supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, gram, negative, bacteria, Tocris Bioscience, Pregnane X Receptor Agonist products

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