Cat. No. 5359
Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S
Biological ActivityPregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559. PMID: 25277138.
Stradi et al (2010) Structural elucidation of the Rifaximin Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858. PMID: 19926422.
Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67. PMID: 15855749.
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Citations are publications that use Tocris products.
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Keywords: Rifaximin, supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, gram, negative, bacteria, Tocris Bioscience, Pregnane X Receptor Agonist products
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