Cat. No. 5359
Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S
Biological ActivityPregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559. PMID: 25277138.
Stradi et al (2010) Structural elucidation of the Rifaximin Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858. PMID: 19926422.
Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67. PMID: 15855749.
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Keywords: Rifaximin, supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, gram, negative, bacteria, Tocris Bioscience, Pregnane X Receptor Agonist products