Cat. No. 5358
Alternative Name: HOE 642
Chemical Name: N-(Aminoiminomethyl)-4-(1-methyleth
Biological ActivitySelective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Harguindey et al (2013) Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 11 282. PMID: 24195657.
Teshima et al (2003) Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108 2275. PMID: 14568900.
Chakrabarti et al (1997) A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 29 3169. PMID: 9405190.
Scholz et al (1995) Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 29 260. PMID: 7736504.
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Keywords: Cariporide, supplier, Cariporide, HOE642, selective, sodium, hydrogen, exchanger, NHE1, inhibitors, inhibits, cardioprotective, cardiomyocytes, ischemia, orally, active, Na+/H+, Tocris Bioscience, Na+/H+ Exchanger Inhibitor products
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