Cat. No. 5358
Alternative Name: HOE 642
Chemical Name: N-(Aminoiminomethyl)-4-(1-methyleth
Biological ActivitySelective Na+/H+ exchanger isoform 1 (NHE1) inhibitor (IC50 values are 0.05, 3 and 1000 μM for NHE1, NHE3 and NHE2 respectively). Attenuates ischemia-induced cardiomyocyte apoptosis in vitro. Reduces cardiac arrhythmia in vivo. Also promotes apoptosis in cancer cells overexpressing NHE1. Orally active.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Harguindey et al (2013) Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs--an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research. J.Transl.Med. 11 282. PMID: 24195657.
Teshima et al (2003) Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation 108 2275. PMID: 14568900.
Chakrabarti et al (1997) A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). J.Mol.Cell.Cardiol. 29 3169. PMID: 9405190.
Scholz et al (1995) Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion. Cardiovasc.Res. 29 260. PMID: 7736504.
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Keywords: Cariporide, supplier, Cariporide, HOE642, selective, sodium, hydrogen, exchanger, NHE1, inhibitors, inhibits, cardioprotective, cardiomyocytes, ischemia, orally, active, Na+/H+, Tocris Bioscience, Na+/H+ Exchanger Inhibitor products
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