DC 260126

Cat. No. 5357

DC 260126 C16H18FNO2S [346692-04-4]

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Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesulfonamide

Biological Activity

Free fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.

Technical Data

M.Wt:
307.38
Formula:
C16H18FNO2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
346692-04-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744. PMID: 23776696.

Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647. PMID: 20888730.

Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557. PMID: 19818732.

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Keywords: DC 260126, supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products

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