Cat. No. 5357
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesu
Biological ActivityFree fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744. PMID: 23776696.
Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647. PMID: 20888730.
Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557. PMID: 19818732.
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Keywords: DC 260126, supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
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