Cat. No. 5357
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesu
Biological ActivityFree fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744. PMID: 23776696.
Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647. PMID: 20888730.
Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557. PMID: 19818732.
If you know of a relevant reference for DC 260126 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses DC 260126 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: DC 260126, supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
Irreversible P2Y12 antagonist; antiplatelet and orally activeBigLEN (rat)
Potent GPR171 agonistBigLEN (mouse)
P2Y1 allosteric antagonistAC 265347
CaSR biased allosteric modulator7α,25-Dihydroxycholesterol
Highly potent GPR183 (EBI2) agonistAR-C 69931 tetrasodium salt
Highly potent P2Y12 antagonistFTY 720
Potent S1P receptor agonist; also immunosuppressantCinacalcet hydrochloride
Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailableAMG 837 hemicalcium salt
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonist
November 8 - 10, 2017