Cat. No. 5357
Chemical Name: N-(4-Butylphenyl)-4-fluorobenzenesu
Biological ActivityFree fatty acid receptor 1 (FFA1/GPR40) antagonist. Inhibits FFA-induced increases in intracellular Ca2+ levels and suppresses palmitic acid potentiated glucose-stimulated insulin secretion in Min6 pancreatic β cells in vitro. Decreases serum insulin levels, improves insulin sensitivity and reduces the number of apoptotic pancreatic β cells in obese diabetic (db/db) rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Sun et al (2013) DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS ONE 8 e66744. PMID: 23776696.
Zhang et al (2010) DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed.Pharmacother. 64 647. PMID: 20888730.
Hu et al (2009) A novel class of antagonists for the FFAs receptor GPR40. Biochem.Biophys.Res.Comm. 390 557. PMID: 19818732.
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Keywords: DC 260126, supplier, DC260126, GPR40, free, fatty, acid, receptors, 1, FFA1, insulin, sensitivity, Tocris Bioscience, Free Fatty Acid Receptor Antagonist products
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