Cat. No. 5355
Chemical Name: N-[3-Chloro-4-[[[2-(methylamino)-6-
Biological ActivityPotent and selective GPR39 agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively). Selective over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Increases GLP-1 levels in vitro and in vivo. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Peukert et al (2014) Discovery of 2-pyridylpyrimidines as the first orally bioavailable GPR39 agonists. ACS Med.Chem.Lett. 5 1114. PMID: 25313322.
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Citations are publications that use Tocris products. Selected citations for TC-G 1008 include:
Mlyniec et al (2016) Potential antidepressant-like properties of the TC G-1008, a GPR39 (zinc receptor) agonist. J Affect Disord. 201 179. PMID: 27235821.
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Keywords: TC-G 1008, supplier, TC-G1008, potent, selective, GPR39, agonists, agonism, Tocris Bioscience, Orphan 7-TM Receptor Agonist products
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