Cat. No. 5351
Chemical Name: 4-(Butylamino)-2-(3-fluorophenyl)-1
Biological ActivityPotent and selective A1 receptor antagonist/inverse agonist. Exhibits high binding affinity at A1 receptor (Ki values are 0.07 and 0.96 nM for rat and human receptors respectively). Reduces basal [35S]-GTPγS binding 44.6% (IC50 = 0.19 nM). Antagonizes the effects of A1 agonist R-PIA (IC50 = 18.3 nM) and exhibits competitive antagonism on CCPA-induced tracheal contractions ex vivo. Displays 217- fold selectively over hA2A receptor and >1000-fold selectivity over hA3 receptor.
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Certificate of Analysis / Safety Data Sheet
Lu et al (2014) PQ-69, a novel and selective adenosine A1 receptor antagonist with inverse agonist activity. Purinergic Signal. 10 619. PMID: 25248972.
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Keywords: PQ 69, supplier, PQ69, Potent, selective, A1, antagonists, receptors, adenosines, inverse, agonists, Tocris Bioscience, A1 Receptor Antagonist products