Cat. No. 5349
Chemical Name: 2-[[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-H
Biological ActivityPotent prostacyclin (PGI2) analog (EC50 values are 0.6, 1.9 and 6.2 nM at DP1, IP and EP2 receptors respectively). Causes vasodilation of human pulmonary arteries and inhibits NFκB nuclear translocation in human alveolar macrophages in vitro.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Whittle et al (2012) Binding and activity of the prostacyclin receptor (IP) agonists, treprostinil and iloprost, at human prostanoid receptors: treprostinil is a potent DP1 and EP2 agonist. Biochem.Pharmacol. 84 68. PMID: 22480736.
Fontana et al (2007) Treprostinil potentiates the positive inotropic effect of catecholamines in adult rat ventricular cardiomyocytes. Br.J.Pharmacol. 151 779. PMID: 17533419.
Raychaudhuri et al (2002) The prostacyclin analogue treprostinil blocks NFκB nuclear translocation in human alveolar macrophages. J.Biol.Chem. 277 33344. PMID: 12082102.
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Citations are publications that use Tocris products.
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Keywords: Treprostinil, supplier, Potent, prostacyclin, PGI2, analogues, DP,IP, EP2, agonists, agonism, vasodilation, pulmonary, hypertension, PPH, Tocris Bioscience, Prostanoid Receptor Agonist products
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