Cat. No. 5348
Chemical Name: 6,8-Bis[(phenylmethyl)thio]octanoic
Biological ActivityPyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) inhibitor. Disrupts tumor cell mitochondrial metabolism, and increases mitochondrial reactive oxygen species (ROS) production in H460 lung carcinoma cells. Has no effect on KGDH activity in normal bronchial epithelial cells. Induces cell death of multiple tumor cell lines selectively over normal cells in vitro. Inhibits tumor growth of H460 and BxPC-3 tumor cell xenografts in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Stuart et al (2014) A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2 4. PMID: 24612826.
Zachar et al (2011) Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J.Mol.Med. (Berl.) 89 1137. PMID: 21769686.
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Keywords: CPI 613, supplier, CPI613, Pyruvate, dehydrogenase, PDH, a-ketoglutarate, dehydrogenase, alpha, KGDH, inhibitors, inhibits, antitumor, active, in, vivo, xenografts, cell, death, Tocris Bioscience, Other Dehydrogenase Inhibitor products