ML 348

Cat. No. 5345

ML 348 C18H17ClF3N3O3 [899713-86-1]

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Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide

Biological Activity

Selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). Exhibits 14-fold selectivity for LYPLA1 over LYPLA2. Also selective over a panel of ~30 other serine hydrolases.

Technical Data

M.Wt:
415.79
Formula:
C18H17ClF3N3O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
899713-86-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Adibekian et al (2013) Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program. PMID: 24624465.

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Keywords: ML 348, supplier, ML348, selective, reversible, lysophospholipase, 1, lypla1, inhibitors, inhibits, Tocris Bioscience, Other Hydrolase Inhibitor products

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