ML 349

Cat. No. 5344

ML 349 C23H22N2O4S2 [890819-86-0]

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Chemical Name: (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone

Biological Activity

Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).

Technical Data

Soluble to 20 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Adibekian et al (2010) Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program. PMID: 24624468.

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Keywords: ML 349, supplier, ML349, selective, reversible, Lysophospholipase, 2, LYPLA2, inhibitors, inhibits, serine, hydrolases, Tocris Bioscience, Other Hydrolase Inhibitor products

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