ML 349

Cat. No. 5344

ML 349 C23H22N2O4S2 [890819-86-0]

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Chemical Name: (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone

Biological Activity

Selective and reversible lysophospholipase 2 (LYPLA2) inhibitor (IC50 = 144 nM). Displays selectively over LYPLA1 and 20 other serine hydrolases (IC50 values are >3000 and >10,000 nM respectively).

Technical Data

M.Wt:
454.56
Formula:
C23H22N2O4S2
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
890819-86-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Adibekian et al (2010) Characterization of a selective, reversible inhibitor of lysophospholipase 2 (LYPLA2). Probe Reports from the NIH Molecular Libraries Program. PMID: 24624468.

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Keywords: ML 349, supplier, ML349, selective, reversible, Lysophospholipase, 2, LYPLA2, inhibitors, inhibits, serine, hydrolases, Tocris Bioscience, Other Hydrolase Inhibitor products

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