NSC 617145

Cat. No. 5340

NSC 617145 C13H10Cl4N2O4 [203115-63-3]

Price and Availability

For NSC 617145 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

Biological Activity

Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Technical Data

M.Wt:
400.04
Formula:
C13H10Cl4N2O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
203115-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497. PMID: 23867477.

Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329. PMID: 24036544.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses NSC 617145 from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: NSC 617145, supplier, NSC617145, Werner, syndrome, helicase, WRN, helicase, inhibitors, inhibits, double, strand, breaks, chromosomal, abnormalities, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area

Pladienolide B

mRNA splicing inhibitor; antitumor

Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Sign-up for new product e-alerts
divider line

Bio-Techne Events

Pharmacology 2016

Pharmacology 2016

December 13 - 15, 2016

London, UK

Booth: 7