NSC 617145

Cat. No. 5340

NSC 617145 C13H10Cl4N2O4 [203115-63-3]

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Chemical Name: 1,1'-(2,2-Dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione

Biological Activity

Werner syndrome helicase (WRN) helicase inhibitor (IC50 = 250 nM); acts synergistically with Mitomycin C (Cat. No. 3258) to induce double-strand breaks and chromosomal abnormalities in vitro.

Technical Data

M.Wt:
400.04
Formula:
C13H10Cl4N2O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
203115-63-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Aggarwal et al (2013) Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73 5497. PMID: 23867477.

Aggarwal et al (2013) Targeting an Achilles' heel of cancer with a WRN helicase inhibitor. Cell Cycle 12 3329. PMID: 24036544.

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Keywords: NSC 617145, supplier, NSC617145, Werner, syndrome, helicase, WRN, helicase, inhibitors, inhibits, double, strand, breaks, chromosomal, abnormalities, Tocris Bioscience, DNA, RNA and Protein Synthesis Inhibitor products

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