PFK 15

Cat. No. 5339

PFK 15 C17H12N2O [4382-63-2]

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Chemical Name: 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

Biological Activity

Selective PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 207 nM). Selective for PFKFB3 over a panel of 96 other kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits lung metastasis of Lewis lung carcinoma cell xenografts in mice.

Technical Data

Soluble to 100 mM in DMSO
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Clem et al (2013) Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol.Cancer Ther. 12 1461. PMID: 23674815.

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Keywords: PFK 15, supplier, PFK15, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, selective, PFKFB3, inhibitors, inhibits, antitumor, Tocris Bioscience, PFKFB3 Inhibitor products

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