PFK 15

Cat. No. 5339

PFK 15 C17H12N2O [4382-63-2]

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Chemical Name: 1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one

Biological Activity

Selective PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 207 nM). Selective for PFKFB3 over a panel of 96 other kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits lung metastasis of Lewis lung carcinoma cell xenografts in mice.

Technical Data

M.Wt:
260.29
Formula:
C17H12N2O
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
4382-63-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Clem et al (2013) Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol.Cancer Ther. 12 1461. PMID: 23674815.

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Keywords: PFK 15, supplier, PFK15, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, selective, PFKFB3, inhibitors, inhibits, antitumor, Tocris Bioscience, PFKFB3 Inhibitor products

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