PK-THPP

Cat. No. 5338

PK-THPP C29H32N4O2 [1332454-07-5]

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Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone

Biological Activity

Potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.

Technical Data

M.Wt:
468.59
Formula:
C29H32N4O2
Solubility:
Soluble to 50 mM in DMSO and to 20 mM in 1eq. HCl with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
1332454-07-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Cotten (2013) TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats. Anesth.Analg. 116 810. PMID: 23460565.

Coburn et al (2012) Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). ChemMedChem 7 123. PMID: 21916012.

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Keywords: PK-THPP, supplier, potent, TASK3, channels, blockers, TWIK, related, acid, sensitive, K+, two, pore, potassium, potassium, K2P9.1, subfamily, member, 9, Tocris Bioscience, Two-P Potassium Channel Blocker products

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