ML 365

Cat. No. 5337

ML 365 C22H20N2O3 [947914-18-3]

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Chemical Name: 2-Methoxy-N-[3-[(3-methylbenzoyl)amino]phenyl]benzamide

Biological Activity

Potent and selective TASK-1 (K2P3.1/KCNK3) channel blocker (IC50 values are 4 and 390 nM at TASK-1 and TASK-3, respectively). Displays little or no inhibition at Kir2.1, voltage-gated potassium channels, KCNQ2 and KV11.1 (hERG).

Technical Data

M.Wt:
360.41
Formula:
C22H20N2O3
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
947914-18-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Flaherty et al (2014) Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorg.Med.Chem.Lett. 24 3968. PMID: 25017033.

Zou et al (2013) ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel. Probe Reports from the NIH Molecular Libraries Program. PMID: 24479195.

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Keywords: ML 365, supplier, ML365, Potassium, channels, subfamily, K, member, 3, k2p3.1, KCNK3, potent, selective, TASK1, inhibitors, inhibits, TASK3, TWIK, related, acid, sensitive, K+, two, pore, potassium, channel, Tocris Bioscience, Two-P Potassium Channel Blocker products

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