Cat. No. 5335
Biological ActivityPotent endogenous vasoconstrictor peptide; derivative of angiotensin (Ang) II. Elicits pressor and renal vasoconstrictor effects in rodents via the AT1 receptor; inhibited by Candesartan (Cat. No. 4791) but not by AT2 receptor ligands in vivo. Displays a similar affinity for AT1 and AT2 receptors as angiotensin II in vitro (Ki values are 1.6 and 2.3 nM at AT1 and AT2 receptors); also increases inositol phosphate accumulation with a similar potency to Ang II (EC50 = 6.7 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Villela et al (2014) Alamandine: a new member of the angiotensin family. Curr.Opin.Nephrol.Hypertens. 23 130. PMID: 24389733.
Coutinho et al (2013) Cardiovascular effects of angiotensin A: A novel peptide of the renin-angiotensin system. J.Renin Angiotensin Aldosterone Syst. 15 480. PMID: 23386282.
Yang et al (2011) Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent. Hypertension 57 956. PMID: 21464395.
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Keywords: Angiotensin A, supplier, Angiotensin, A, II, receptors, potent, endogenous, vasoconstrictor, peptide, AT1, AT2, agonists, Tocris Bioscience, Non-selective AT Receptor Agonist products