Cat. No. 5332
Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyr
Biological ActivityHigh affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086. PMID: 25271708.
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Keywords: SP 141, supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products
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March 18 - 22, 2017
Little Rock, ARK, USA