SP 141

Cat. No. 5332

SP 141 C22H16N2O [1253491-42-7]

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Chemical Name: 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole

Biological Activity

High affinity MDM2 inhibitor (Ki = 28 nM); directly binds MDM2. Inhibits MDM2 expression and induces MDM2 autoubiquitination and proteasomal degradation. Attenuates growth of breast cancer xenograft tumors. Cell permeable.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Wang et al (2014) The pyrido[b]indole MDM2 inhibitor SP-141 exerts potent therapeutic effects in breast cancer models. Nat.Commun. 5 5086. PMID: 25271708.

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Keywords: SP 141, supplier, SP141, High, affinity, MDM2, inhibitors, inhibits, antitumor, antitumour, Mouse, double, minute, 2, homolog, Tocris Bioscience, Ubiquitin E3 Ligase Inhibitor products

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