Cat. No. 5331
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trime
Biological ActivityBET bromodomain inhibitor. Downregulates Myc expression, causes G1 cell cycle arrest and attenuates cell proliferation in human pancreatic neuroendocrine tumors. Arrests the growth of T cell acute lymphoblastic leukemia cells in vitro (EC50 = 91.2 nM). Also enhances the antitumor effect of rapamycin (Cat. No. 1292) in vitro and attenuates rapamycin induced Akt activation. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wong et al (2014) The bromodomain and extra-terminal inhibitor CPI203 enhances the antiproliferative effects of rapamycin on human neuroendocrine tumors. Cell Death Dis. 5 e1450. PMID: 25299775.
King et al (2013) The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153 1552. PMID: 23791182.
If you know of a relevant reference for CPI 203 please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses CPI 203 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: CPI 203, supplier, CPI203, BET, BRD4, domain, inhibitors, inhibits, (+)-JQ1, analogue, analog, 4499, Myc, G1, cell, cycle, arrest, antitumor, rapamycin, AKT, Tocris Bioscience, Bromodomain Inhibitor products
Find multiple products by catalog number
New Products in this Area
Histone H3 peptideTC AC 28
High affinity BET bromodomain ligandTP 472N
Negative control for TP 472 (Cat. No. 6000).TP 472
Potent BRD9/7 inhibitorBAY 299
Potent and selective BRD1 and TAF1 inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.