CKI 7 dihydrochloride
Cat. No. 5329
Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquin
Biological ActivityCasein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169. PMID: 19671662.
Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618. PMID: 19591487.
Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60. PMID: 14710188.
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Keywords: CKI 7 dihydrochloride, supplier, CKI7, dihydrochloride, casein, kinases, CK1, stem, cells, retinal, differentiation, ESCs, iPSCs, embryonic, induced, pluripotent, Tocris Bioscience, Casein Kinase 1 Inhibitor products
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