CKI 7 dihydrochloride

Cat. No. 5329

CKI 7 dihydrochloride C11H12ClN3O2S.2HCl [1177141-67-1]

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Chemical Name: N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride

Biological Activity

Casein kinase 1 (CK1) inhibitor. Also inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation from human ESCs and iPSCs in combination with SB 431542 (Cat. No. 1614) and Y-27632 (Cat. No. 1254).

Technical Data

M.Wt:
358.67
Formula:
C11H12ClN3O2S.2HCl
Solubility:
Soluble to 20 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
1177141-67-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Osakada et al (2009) In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J.Cell Sci. 122 3169. PMID: 19671662.

Peifer et al (2009) 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J.Med.Chem. 52 7618. PMID: 19591487.

Rena et al (2004) D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep. 5 60. PMID: 14710188.

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Keywords: CKI 7 dihydrochloride, supplier, CKI7, dihydrochloride, casein, kinases, CK1, stem, cells, retinal, differentiation, ESCs, iPSCs, embryonic, induced, pluripotent, Tocris Bioscience, Casein Kinase 1 Inhibitor products

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