Cat. No. 5328
Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-o
Biological ActivityS1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806. PMID: 25254944.
Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704. PMID: 20097776.
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Citations are publications that use Tocris products. Selected citations for TY 52156 include:
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.
Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454. PMID: 26690412.
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Keywords: TY 52156, supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products
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