TY 52156

Cat. No. 5328

TY 52156 C18H19Cl2N3O [934369-14-9]

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Chemical Name: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide

Biological Activity

S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

Technical Data

M.Wt:
364.27
Formula:
C18H19Cl2N3O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
934369-14-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806. PMID: 25254944.

Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704. PMID: 20097776.

If you know of a relevant reference for TY 52156 please let us know.

Citations are publications that use Tocris products. Selected citations for TY 52156 include:

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184. PMID: 26419927.

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454. PMID: 26690412.

Do you know of a great paper that uses TY 52156 from Tocris? If so please let us know.

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Keywords: TY 52156, supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Tocris Bioscience, Sphingosine-1-Phosphate Receptor Antagonist products

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