CHR 6494 trifluoroacetate

Cat. No. 5326

CHR 6494 trifluoroacetate C16H16N6.CF3CO2H [1458630-17-5]

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Chemical Name: 3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate

Biological Activity

Potent and selective haspin kinase inhibitor (IC50 = 2 nM). Selective over 27 other protein kinases including Aurora B kinase. Induces cell cycle arrest at G2/M, inhibits cell proliferation and promotes apoptosis in multiple cancer cell lines. Inhibits angiogenesis ex vivo and attenuates tumor growth of HCT-116 xenografts in rats.

Technical Data

M.Wt:
406.36
Formula:
C16H16N6.CF3CO2H
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
1458630-17-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Huertas et al (2012) Antitumor activity of a small-molecule inhibitor of the histone kinase Haspin. Oncogene 31 1408. PMID: 21804608.

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Keywords: CHR 6494 trifluoroacetate, supplier, CHR6494, trifluoroacetate, potent, selective, haspin, kinases, inhibitors, inhibits, cell, cycle, arrest, cell, proliferation, apoptosis, Tocris Bioscience, Haspin Inhibitor products

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