Cat. No. 5325

Rosiglitazone C18H19N3O3S [122320-73-4]

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Alternative Name: BRL 49653

Chemical Name: 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione

Biological Activity

Potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Willson et al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907.

Lehmann et al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 270 12953. PMID: 7768881.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Rosiglitazone include:

Matsa et al (2016) Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. Cell Stem Cell. 19 311. PMID: 27545504 .

Ahlem et al (2011) Studies of the pharmacology of 17α-ethynyl-androst-5-ene-3β,7β,17β-triol, a synthetic anti-inflammatory androstene. Int J Clin Exp Med 4 119. PMID: 21686136.

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Keywords: Rosiglitazone, supplier, BRL49653, High, affinity, selective, PPAR, agonist, thiazolidinedione, TZD, derivative, antidiabetic, agent, Tocris Bioscience, PPARγ Agonist products

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