M8 B hydrochloride

Cat. No. 5324

M8 B hydrochloride C22H24N2O3S.HCl [883976-12-3]

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Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

Biological Activity

Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.

Technical Data

M.Wt:
432.96
Formula:
C22H24N2O3S.HCl
Solubility:
Soluble to 10 mM in water with sonication and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
883976-12-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Almeida et al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086. PMID: 22323721.

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