M8 B hydrochloride

Cat. No. 5324

M8 B hydrochloride C22H24N2O3S.HCl [883976-12-3]

Price and Availability

For M8 B hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride

Biological Activity

Potent and selective TRPM8 channel blocker. Blocks cold- and icilin-induced TRPM8 activation in vitro (IC50 values are 7.8 and 26.9 nM respectively). Exhibits no effect at other TRP channels (IC50 > 20 μM). Reduces body temperature in vivo.

Technical Data

Soluble to 10 mM in water with sonication and to 100 mM in DMSO
>99 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Almeida et al (2012) Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J.Neurosci. 32 2086. PMID: 22323721.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses M8 B hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: M8 B hydrochloride, supplier, potent, selective, TRPM8, channel, blockers, blocks, M8B, hydrochloride, transient, receptors, potential, melastatin8, Tocris Bioscience, TRPM Blocker products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

divider line

New Products in this Area

PF 05105679

Selective TRPM8 blocker

M 084 hydrochloride

TRPC4/5 channel blocker; antidepressant and anxiolytic

A 425619

Potent TRPV1 antagonist

RN 9893 hydrochloride

Potent and selective TRPV4 antagonist

Sign-up for new product e-alerts
divider line

Bio-Techne Events

ASCB 2016

ASCB 2016

December 3 - 7, 2016

San Francisco, CA,