Cat. No. 5323
Chemical Name: 3-[(3-Methoxybenzoyl)amino]-4-(4-me
Biological ActivityWD repeat-containing protein 5 (WDR5) antagonist (Kd = 450 nM). Disrupts WDR5 interaction with MLL and inhibits MLL core complex methyltransferase activity in vitro. Has no effect on a panel of seven other methyltransferases, including SETD7.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Senisterra et al (2013) Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5. Biochem.J. 449 151. PMID: 22989411.
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Keywords: WDR5 0103, supplier, WDR50103, WDR5, antagonists, MLL, methyltransferases, epigenetics, WD, repeat-containing, Tocris Bioscience, Lysine Methyltransferase products
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