Cat. No. 5320
Alternative Name: Carbon monoxide releasing molecule 3
Chemical Name: Tricarbonylchloro(glycinato)rutheni
Biological ActivityWater-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Filippo et al (2012) Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 385 137. PMID: 22038495 .
Bani-Hani et al (2006) Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 318 1315. PMID: 16772536.
Sawle et al (2005) Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 145 800. PMID: 15880142.
Foresti et al (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 142 453. PMID: 15148243.
Clark et al (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 93 e2. PMID: 12842916.
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Keywords: CORM 3, supplier, CORM3, Water-soluble, carbon, monoxide-releasing, molecules, 3, CORM3, anti-inflammatory, cardioprotective, Tocris Bioscience, Miscellaneous Compound products