CORM 3

Cat. No. 5320

CORM 3 C5H4ClNO5Ru [475473-26-8]

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Alternative Name: Carbon monoxide releasing molecule 3

Chemical Name: Tricarbonylchloro(glycinato)ruthenium

Biological Activity

Water-soluble carbon monoxide-releasing molecule. Suppresses thrombin-induced nitrite release in BV-2 microglia. Protects isolated rats hearts from reperfusion damage in vitro and is cardioprotective in a rat myocardial infarction model in vivo. Also prolongs survival of transplanted hearts in mice. Exhibits anti-inflammatory and vasorelaxant effects.

Technical Data

M.Wt:
294.61
Formula:
C5H4ClNO5Ru
Solubility:
Soluble to 100 mM in water
Storage:
Store at -20°C
CAS No:
475473-26-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Filippo et al (2012) Acute myocardial infarction in streptozotocin-induced hyperglycaemic rats: protection by a carbon monoxide-releasing molecule (CORM-3). Naunyn Schmiedebergs Arch.Pharmacol. 385 137. PMID: 22038495 .

Bani-Hani et al (2006) Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J.Pharmacol.Exp.Ther. 318 1315. PMID: 16772536.

Sawle et al (2005) Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br.J.Pharmacol. 145 800. PMID: 15880142.

Foresti et al (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br.J.Pharmacol. 142 453. PMID: 15148243.

Clark et al (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ.Res. 93 e2. PMID: 12842916.

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Keywords: CORM 3, supplier, CORM3, Water-soluble, carbon, monoxide-releasing, molecules, 3, CORM3, anti-inflammatory, cardioprotective, Tocris Bioscience, Miscellaneous Compound products

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