Cat. No. 5315
Alternative Name: PST 2238
Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,
Biological ActivityNa+/K+ ATPase modulator. Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kirshenbaum et al (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 108 18144. PMID: 22025725.
Ferrari et al (2010) Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 1802 1254. PMID: 20083196.
Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529. PMID: 16467500.
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Keywords: Rostafuroxin, supplier, PST2238, Ouabain, inhibitors, inhibits, Na+/K+, ATPase, pump, modulators, antihypertensive, Tocris Bioscience, Na+/K+ ATPase Modulator products