Cat. No. 5315
Alternative Name: PST 2238
Chemical Name: 3β,5β,14β)-21,23-Epoxy-24-norchola-20,
Biological ActivityNa+/K+ ATPase modulator. Normalizes renal Na+/K+ ATPase pump function in mutant adducin- and endogenous ouabain-dependent forms of hypertension. Reduces blood pressure in Milan hypersensitive rats. Controls mania-like behaviors in Myshkin mice having a Na+/K+ ATPase α3 subunit mutation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kirshenbaum et al (2011) Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump. Proc.Natl.Acad.Sci.U.S.A. 108 18144. PMID: 22025725.
Ferrari et al (2010) Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension. Biochim Biophys Acta. 1802 1254. PMID: 20083196.
Ferrari (2006) Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension. Am.J.Physiol.Regul.Integr.Comp.Physiol. 290 529. PMID: 16467500.
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Keywords: Rostafuroxin, supplier, PST2238, Ouabain, inhibitors, inhibits, Na+/K+, ATPase, pump, modulators, antihypertensive, Tocris Bioscience, Na+/K+ ATPase Modulator products
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