Cat. No. 5314
Chemical Name: 2-[(2-Nitro-9H-fluorene-9-ylidene)m
Biological ActivityHigh affinity and selective activator of Bax (Ki = 43.3 nM). Binds to the S184 binding pocket to block Bax phosphorylation. Does not bind to other Bcl-2 family members, including Bcl-2, Bak and Bid. Facilitates Bax insertion into the mitochondrial membrane and promotes Bax-dependent cytochrome c release. Induces apoptosis in lung cancer cell lines expressing high levels of Bax selectively over normal cells expressing low levels of Bax. Represses tumor growth of A549 lung cancer xenografts in mice.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Xin et al (2014) Small-molecule Bax agonists for cancer therapy. Nat.Commun. 5 4935. PMID: 25230299.
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April 22 - 26, 2017
Chicago, IL, USA