Cat. No. 5313
Alternative Name: Varespladib
Chemical Name: 2-[[3-(2-Amino-2-oxoacetyl)-2-ethyl
Biological ActivitySelective secreted phospholipase A2 (sPLA2) inhibitor (IC50 = 50 - 750 nM for a range of sPLA2 isoforms). Has no effect on cytosolic PLA2 or COX-1 and COX-2 activity. Attenuates sPLA2-induced thromboxane formation in bronchoalveolar lavage (BAL) cells. Also suppresses sPLA2-induced contractions of lung pleural strips ex vivo. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Oslund et al (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J.Med.Chem. 51 4708. PMID: 18605714.
Snyder et al (1999) Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J.Pharmacol.Exp.Ther. 288 1117. PMID: 10027849.
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Keywords: LY 315920, supplier, LY315920, selective, secreted, phospholipase, A2, sPLA2, inhibitors, inhibits, orally, available, Varespladib, Tocris Bioscience, Phospholipase Inhibitor products