BRACO 19 trihydrochloride

Cat. No. 5312new

BRACO 19 trihydrochloride C35H43N7O2.3HCl [1177798-88-7]

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Chemical Name: N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride

Biological Activity

Telomerase inhibitor (IC50 = 115 nM). Inhibits expression of human telomerase reverse transcriptase (hTERT), induces cellular senescence and inhibits growth of uterine cancer cells in vitro. Inhibits growth of uterine tumor xenografts in mice.

Technical Data

M.Wt:
703.14
Formula:
C35H43N7O2.3HCl
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
1177798-88-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Burger et al (2005) The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res. 15 1489. PMID: 15735037.

Gowan et al (2002) A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol.Pharmacol. 61 1154. PMID: 11961134.

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Keywords: BRACO 19 trihydrochloride, supplier, BRACO19, trihydrochloride, telomerase, inhibitor, inhibits, Tocris Bioscience, Telomerase Inhibitor products

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