RHPS 4 methosulfate

Cat. No. 5311

RHPS 4 methosulfate C22H17F2N2.CH3O4S [390362-78-4]

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Chemical Name: 3,11-Difluoro-6,8,13-trimethylquino[4,3,2-kl]acridinium methylsulfate

Biological Activity

Telomerase inhibitor. Inhibits growth of medulloblastoma and glioblastoma cells in vitro. Induces telomere injury and apoptosis, and reduces growth in CG5 breast cancer cell xenografts in mice.

Technical Data

Soluble to 10 mM in water with gentle warming and to 20 mM in DMSO
>98 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lagah et al (2014) RHPS4 G-quadruplex ligand induces anti-proliferative effects in brain tumor cells. PLoS One 9 e86187. PMID: 24454961.

Phatak et al (2007) Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br.J.Cancer 96 1223. PMID: 17406367.

Salvati et al (2007) Telomere damage induced by the G-quadruplex ligand RHPS4 has an antitumor effect. J.Clin.Invest. 117 3236. PMID: 17932567.

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Keywords: RHPS 4 methosulfate, supplier, RHPS4, methosulfate, telomerase, inhibitors, inhibits, cancer, telomere, Tocris Bioscience, Telomerase Inhibitor products

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