Cat. No. 5310
Chemical Name: N2-[2-Methoxy-4-[4-(4-methyl-1-pipe
Biological ActivityPotent anaplastic lymphoma kinase (ALK) inhibitor (IC50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK+ T cell anaplastic large-cell lymphoma (ALCL) cells in vitro. Suppresses tumor growth of NPM-ALK+ ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Awad and Shaw (2014) ALK Inhibitors in Non-Small Cell Lung Cancer: Crizotinib and Beyond. Clin.Adv.Hematol.Oncol. 12 429. PMID: 25322323.
George et al (2014) The ALK inhibitor ASP3026 eradicates NPM-ALK+ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget 5 5750. PMID: 25026277.
Mori et al (2014) The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 induces tumor regression and prolongs survival in non-small cell lung cancer model mice. Mol.Cancer Ther. 13 329. PMID: 24419060.
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Keywords: ASP 3026, supplier, ASP3026, potent, alk, inhibitors, inhibits, anaplastic, lymphoma, kinases, tyrosine, ack, ros1, crizotinib, npm-alk, non-small, cell, lung, cancer, antitumor, TNK2, tyrosine, kinase, non-receptor, 2, Tocris Bioscience, ALK Inhibitor products
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