SC 560

Cat. No. 1550

SC 560 C17H12ClF3N2O [188817-13-2]

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Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole

Biological Activity

Highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.

Technical Data

M.Wt:
352.74
Formula:
C17H12ClF3N2O
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
188817-13-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735. PMID: 15867369.

Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475. PMID: 15974942.

Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313. PMID: 9789085.

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Keywords: SC 560, supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, SC560, Tocris Bioscience, Cyclooxygenase Inhibitor products

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