Cat. No. 1549
Alternative Name: AHPN
Chemical Name: 6-(4-Hydroxy-3-tricyclo[22.214.171.124,7]
Biological ActivitySynthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283. PMID: 21990348.
Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44. PMID: 12566985.
If you know of a relevant reference for CD 437 please let us know.
Citations are publications that use Tocris products. Selected citations for CD 437 include:
Kelley (2017) Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells. PLoS One 12 (5) e0178116. PMID: 28552962.
Brigger et al (2015) Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861. PMID: 26313912.
Do you know of a great paper that uses CD 437 from Tocris? If so please let us know.
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Keywords: CD 437, supplier, RARγ, RARgamma-selective, agonists, RAR, RAMBA, Retinoic, Acid, Receptors, peroxisome, proliferator-activating, CD437, Tocris Bioscience, Retinoic Acid Receptor Agonist products
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