CD 437

Cat. No. 1549

CD 437 C27H26O3 [125316-60-1]

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Alternative Name: AHPN

Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid

Biological Activity

Synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.

Technical Data

M.Wt:
398.5
Formula:
C27H26O3
Solubility:
Soluble to 20 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
125316-60-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wang et al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci U.S.A. 108 18283. PMID: 21990348.

Zhao and Spanjaard (2003) The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis. J.Biomed.Sci. 10 44. PMID: 12566985.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CD 437 include:

Brigger et al (2015) Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity. J Neurosci 6 e1861. PMID: 26313912.

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View Related Products by Product Action

Keywords: CD 437, supplier, RARγ, RARgamma-selective, agonists, RAR, RAMBA, Retinoic, Acid, Receptors, peroxisome, proliferator-activating, CD437, Tocris Bioscience, Retinoic Acid Receptor Agonist products

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